THE BEHAVIOR OF HAPTEN-POLY-L-LYSINE CONJUGATES AS COMPLETE ANTIGENS IN GENETIC RESPONDER AND AS HAPTENS IN NONRESPONDER GUINEA PIGS
نویسندگان
چکیده
منابع مشابه
The Behavior of Hapten-poly-l-lysine Conjugates as Complete Antigens in Genetic Responder and as Haptens in Nonresponder Guinea Pigs
30 to 40% of Hartley strain guinea pigs have previously been demonstrated to possess a dominant autosomal gene which enables them to recognize the antigenicity of hapten-poly-L-lysine conjugates as expressed by the development of both antihapten antibodies and delayed hypersensitivity to the immunizing antigen. In the present study, it was shown that PLL alone was weakly antigenic in such genet...
متن کاملT H E Behavior of Hapten-poly-l-lysine Conjugates as Complete Antigens in Genetic Responder and as Haptens in Nonresponder Guinea Pigs* by Ira Green,$ M.d., William E. Paul,§ M.d., Ai~d
About 30 to 40 % of random bred Hartley strain (1) and all strain 2 guinea pigs (2) recognize hapten-poly-I.-lysine conjugates (H-PLL) as antigens. Strain 13 guinea pigs (2), mice, rats, and rabbits (3) do not make an immune response to these compounds. The immune response of guinea pigs to H-PLL conjugates has been shown to" be controlled by a dominant autosomal gene (2, 4). Contrasting with t...
متن کاملSTUDIES ON ARTIFICIAL ANTIGENS III. THE GENETIC CONTROL OF Tile IMMUNE RESPONSE TO HAPTEN- POLY-L-LYSINE CONJUGATES IN GUINEA
Previous studies on the genetic transmission of the capacity for an immune response have shown that there is a statistically significant relation between the abilities of parents and of offspring to respond to a given antigen (1-3). Mendelian genetic patterns were not observed, however, possibly because of the structural complexity of the immunizing antigens employed. Poly-L-aamino acids and ha...
متن کاملHapten-carrier relationships.
The ability of guinea pigs to recognize poly-I,-lysine (PLL), and hapten conjugates of PLL (H-PLL) as antigens is under the control of a single autosomal dominant gene which we will refer to as the PLL gene (1-3). Responder animals carrying this gene form specific antihapten antibodies and display delayed hypersensitivity reactions after immunization with H-PLL conjugates such as 2,4-dinitrophe...
متن کاملGeneration of T cell colonies from responder strain 2 guinea pigs that recognize the copolymer L-glutamic acid, L-lysine in association with nonresponder strain 13 Ia antigens
T cells from nonimmune responder strain 2 guinea pigs were primed in vitro to the copolymer GL in association with allogeneic, nonresponder strain 13 PEC. T cells that recognized GL in association with strain 13 Ia were separated from alloreactive T cells by cloning the population in soft agar following the priming in liquid culture. The existence of T cells of responder origin that recognize a...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1966
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.123.5.859